How do human rights issues work at the international and regional levels? As an international organization, the role of the United Nations has become increasingly complex. Today, its main organs - including the Security Council, the General Assembly, and the Human Rights Council - play key roles in the negotiation of new treaties but also in ensuring that treaty provisions are upheld. At the same time, the UN system needs to work closely with other international organizations including the International Criminal Court and civil society. At the regional level, we have seen the development of new processes both within established international organizations such as the European Union but also growing capacity in less formal arrangements such as the Pacific Alliance. The papers in this panel highlight these mechanisms at the regional and international levels while simultaneously interrogating the role played by states, international organizations, and civil society.