Geographies of innovation and new technologies clearly indicate a particular concentration on metropolises as centres of scientific excellence and socio-economic development. Such metropolises clearly vary from other big urban conurbations and from non-metropolitan regions because of their particular settings and the attitudes of the people, who are living there. High levels of education, academic excellence and competences in the engineering and marketing of new products characterise the orientations of those who locate there. Their interest in new opportunities provides for new arrangements and a high diversity of innovative processes. Since metropolises agglomerate such individuals and labour markets, there is also a large number of people who share this attitude and find job opportunities. Metropolises, thus, provide for a culture-technology nexus and serve the processes which help networking among these locations. The metropolitan agglomeration of such attitudes provides a situation where leading edge research is established and new technologies are developed, because they can find partners in metropolises more easily. Consequently, culture allows advanced participation and creativity. In relation with government programmes metropolises can provide as a culture-technology nexus.